Nayantara was born on 8th November 1984 as an Orthodox Syrian Christian in Tiruvalla, Pathanamthitta District, Kerala. She did her schooling at various parts of India (Delhi, Bombay, Calcutta, Punjab and Karnataka) as her father was an Air Force Official. She joined Balikamadom High School, Thiruvalla for +2, then joined Marthoma college in Thiruvalla for her bachelors degree (English Literature).
She became interested in acting after getting good exposure from college. She admits herself that the encouragement her friend Mahesh Kadammanitta gave, helped her a lot to improve. While at college, she was chosen by director Satyan Anthikkad and was cast opposite Jayaram in Mansinakkare. After that, she played a ghost who falls in love with the hero Mohanlal in Fazil’s Vismayathumbathu. She played opposite Sarath Kumar in Ayya. She acted with Rajnikanth in Chandramukhi. Her later films are Natturaajavu (Malayalam), Thaskaraveeran (Malayalam), Vallavan (Tamil), Gajini (Tamil), Yogi (Telugu) etc. She is now busy in the Tamil & Telugu film industry. She was admired by many for her bold acting in the latest Tamil flick Billa.